673Comparative Effectiveness of Vancomycin vs Early Daptomycin for MRSA Bacteremia with Vancomycin MIC >1 mg/L: A Multicenter Evaluation

نویسندگان

  • Pamela Moise
  • Darren Culshaw
  • Annie Wong-Beringer
  • Joyce Bensman
  • Kenneth Lamp
  • Winter J. Smith
  • Karri Bauer
  • Debra Goff
  • Robert Adamson
  • Kimberly Leuthner
  • Michael Virata
  • James A. Mckinnell
  • Saira B. Chaudhry
  • Romic Eskandarian
  • Thomas Lodise
  • Katherine Reyes
  • Marcus Zervos
چکیده

MRSA Bacteremia with Vancomycin MIC >1 mg/L: A Multicenter Evaluation Pamela Moise, PharmD; Darren Culshaw, PharmD; Annie Wong-Beringer, PharmD; Joyce Bensman, PharmD; Kenneth Lamp, PharmD; Winter J. Smith, PharmD; Karri Bauer, PharmD; Debra Goff, PharmD; Robert Adamson, PharmD; Kimberly Leuthner, PharmD; Michael Virata, MD; James A. Mckinnell, MD; Saira B. Chaudhry, PharmD, MPH; Romic Eskandarian, PharmD; Thomas Lodise, PharmD; Katherine Reyes, MD; Marcus Zervos, MD; Cubist Pharmaceuticals, Lexington, MA; Huntington Hospital, Los Angeles, CA; University of Southern California, Los Angeles, CA; University of Oklahoma Health Sciences Center, Oklahoma City, OK; Ohio State University Medical Center, Columbus, OH; St. Barnabas Health Care System, Livingston, NJ; University Medical Center of Southern Nevada, Las Vegas, NV; Hospital of Saint Raphael, New Haven, CT; Torrance Memorial Medical Center, Torrance, CA; Infectious Disease Clinical Outcomes Research Unit (ID-CORE) at Los Angeles Biomedical Research Institute, Torrance, CA; Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Piscataway, NJ; Glendale Adventist Medical Center, Glendale, CA; Albany College of Pharmacy, Albany, NY; Henry Ford Hospital, Detroit, MI

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منابع مشابه

Case report of a successful treatment of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and MRSA/vancomycin-resistant Enterococcus faecium cholecystitis by daptomycin.

A 72-year-old man, receiving 8 mg daptomycin/kg body weight/day for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, was diagnosed with MRSA/vancomycin-resistant Enterococcus faecium (VRE) cholecystitis (daptomycin MIC values, 1 and 2 mg/liter, respectively). After the fifth drug dose, the bile concentration of daptomycin was 66 mg/liter 5 min after drug administration, with the b...

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Early use of daptomycin versus vancomycin for methicillin-resistant Staphylococcus aureus bacteremia with vancomycin minimum inhibitory concentration >1 mg/L: a matched cohort study.

BACKGROUND Recent reports have described decreased effectiveness with vancomycin treatment for methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) when the vancomycin minimum inhibitory concentration (MIC) is >1 µg/mL. METHODS This matched, retrospective cohort study compared the clinical effectiveness of daptomycin with that of vancomycin for the treatment of MRSAB with vancomycin...

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Impact of Molecular Epidemiology and Reduced Susceptibility to Glycopeptides and Daptomycin on Outcomes of Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was associated with high mortality, but the risk factors associated with mortality remain controversial. METHODS A retrospective cohort study was designed. All patients with MRSA bacteremia admitted were screened and collected for their clinical presentations and laboratory characteristics. Minimum inhibitory concentrati...

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Daptomycin Improves Outcomes Regardless of Vancomycin MIC in a Propensity-Matched Analysis of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections.

Vancomycin remains the mainstay treatment for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) despite increased treatment failures. Daptomycin has been shown to improve clinical outcomes in patients with BSIs caused by MRSA isolates with vancomycin MICs of >1 mg/liter, but these studies relied on automated testing systems. We evaluated the outcomes of BSIs cause...

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Vancomycin Creep and Daptomycin Minimum Inhibitory Concentra- tion in Methicillin-Resistant Staphylococcus aureus

Objective: To determine the in vitro activity of daptomycin and vancomycin against 50 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from blood and pus specimens. Material and methods: Fifty consecutive MRSA were isolated from pus (n=25) and blood (n=25) were included in the study. Oxacillin susceptibility was determined by cefoxitin disc diffusion, green colored colonie...

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عنوان ژورنال:

دوره 1  شماره 

صفحات  -

تاریخ انتشار 2014